Immunotoxic Effect Dose Cisplatin in of Low Mice

The immunosuppressive effects of cisplatin at relatively low doses were investigated in CD-1 mice, Mice were injected intraperitonea]ly with 8, 40 and 20e yglkg cisplatin for 10 days, A decrease in bedy and thymus weights was observed at 200Ag!kg, Though there were no dose-related effects on the IgM antibody response to sheep erythrocytes, a statistically significant reduction of the contact hypersensitivity response (CHR) was seen at 200#g/kg. Ih vivo and in vitro effects of cisplatin on Tand B-tymphocyte function were assessed by proliferative respense to concanavalin A and lipepolysaccharide, respectively, Cisplatin inhibited splenic T-lymphocyte function more than splenic B-iymphocyte function, These data indicate that a relatively low dose of cisplat{n induce immunosuppressive effects jn mice with a greater effect on T-lymphocytes than the B-lymphocytes.